The fights at UFC Apex can be seen on ESPN+, with the main card starting at 4 p.m. ET and the prelims at 1 p.m.
Dern (11-1) has won four fights in a row, most recently a first-round submission of Nina Nunes in April. Dern is No. 6 in the ESPN strawweight rankings.
The fourth-ranked Rodriguez (14-1-2) is coming off a victory over Michelle Waterson by unanimous decision in May and is on a two-fight winning streak.
How to watch the fights
Watch all of the fights on ESPN+. Download the ESPN App
Don’t have ESPN+? Get it here.
There’s also FightCenter, which offers live updates for every UFC card.
Saturday’s fight card
ESPN+, 4 p.m. ET
Strawweight: Mackenzie Dern vs. Marina Rodriguez
Welterweight: Randy Brown vs. Jared Gooden
Men’s flyweight: Tim Elliott vs. Matheus Nicolau
Women’s flyweight: Sabina Mazo vs. Mariya Agapova
Middleweight: Phil Hawes vs. Deron Winn
ESPN+, 1 p.m. ET
Men’s bantamweight: Chris Gutierrez vs. Felipe Colares
Heavyweight: Alexandr Romanov vs. Jared Vanderaa
Men’s featherweight: Charles Rosa vs. Damon Jackson
Strawweight: Loopy Godinez vs. Silvana Gomez Juarez
Lightweight: Steve Garcia vs. Charlie Ontiveros