In the main event, UFC middleweight champion Israel Adesanya will try to defend his title against rival Alex Pereira. Pereira has defeated Adesanya twice in kickboxing, but this will be the first time they meet in mixed martial arts.
Check out UFC 281 results below.
Main card (ESPN+ PPV at 10 p.m. ET)
Prelims (ESPN+/ESPNN at 8 p.m. ET)
Early Prelims (ESPN+ at 6 p.m. ET)